Down The Tylenol Rabbitol

Tylenol is in the news. So let’s go down the Tylenol rabbitol.

First of all, let’s establish a clarification:

Tylenol = Acetaminophen = Paracetamol

It’s a painkiller in the form of a pill. Its major rivals are Aspirin and Ibuprofen.

Now, let me do this in steps.

Trump says, “Don’t use Tylenol.”

Typical Trump. Exaggerating a bit. The US Government actually wants to urge caution.

Wes Streeting heard this, and was “aghast” said an aide.

Why? What does Streeting know? Is he opposed to caution? Or just exaggeration?

Streeting went on breakfast television.

I trust doctors over President Trump, frankly, on this,” he said. “I’ve just got to be really clear about this: there is no evidence to link the use of paracetamol by pregnant women to autism in their children. None. So I would just say to people watching: don’t pay any attention whatsoever to what Donald Trump says about medicine. In fact, don’t even take my word for it, as a politician – listen to British doctors, British scientists, the NHS.

No evidence? Nought?

And, hang, on, ‘don’t take your word for it as a politician’?

This sounds like a real conundrum.

  1. The politician says, ‘Don’t trust politicians: trust scientists.’
  2. The citizen replies, ‘I won’t trust you, thanks: but, since you say trust scientists, I won’t trust scientists either.’

The Guardian finds a lot of experts to confirm the Streeting analysis:

  • The Medicines and Healthcare products Regulatory Agency
  • NHS England
  • The Royal College of GPs
  • The Royal Pharmaceutical Society
  • The UK Health Security Agency
  • The National Autistic Society
  • The World Health Organisation
  • Helen Bedford, a Professor of Child Health at University College London
  • Dr Susanna Kola-Palmer, a psychologist at the University of Huddersfield
  • Heidi Larson, a Professor of Anthropology at the London School of Hygiene and Tropical Medicine, writing in the Lancet

I like making a list, as, damn it, whenever I read one of these articles I cannot see clearly. In fact, I am fairly sure this is the point: the Guardian wants to bombard the reader with authorities all sounding forbidding and scientific.

I valiantly decide to venture down the rabbitol a bit further.

Helen Bedford, Professor, UCL said: “I was horrified, because it’s not evidence-based and he is the most powerful man in the world.”

I checked this professor. She says she has a background in nursing, health visiting and vaccine communicating. Yes, she has written academic articles on vaccine uptake. Not an expert on vaccines, then, but an expert on vaccine hesitancy. A behavioural scientist, then. She is a believer in “optimal uptake”. A bit of a branch Covidian.

Dr Susanna Kola-Palmer, Reader at Huddersfield, said:

People are prone to authority bias, trusting and believing what someone in authority says just because they are an authority figure, not necessarily because they are right. Donald Trump, as the US President, is a powerful public figure and therefore lots of people will accept what he says without questioning it.

I agree. We do have an authority bias. In my case, I seem to find myself trusting and believing what is said by, er, the Medicines and Healthcare products Regulatory Agency, NHS England, the Royal College of GPs, the Royal Pharmaceutical Society, the UK Health Security Agency, the National Autistic Society, the World Health Organisation. These are authorities, aren’t they? However, perhaps, on Dr Susanna Kola-Palmer’s logic, I ought to distrust them. But then I would be taking that on her authority.

By the way, she works on health psychology. Hell’s bells, she is also an authority on ‘vaccine hesitancy’. Vaccine hesitancy. Does anyone study this philosophically, that is neutrally? Or do they all study it politically, i.e., by advocating something, by taking sides? I suspect the latter. In fact, I know it.

By the way, the Guardian says: “President says [blah blah blah], assertion contradicted by research.”

Now, “blah, blah, blah” could be anything, and the Guardian would oppose it, say it was not in accordance with research, evidence, fact. But, excuse me, what research exactly, which fact, whose evidence?

And of course the Guardian, which parroted all the 2020 COVID-19 heavy science without restraint, cannot bring itself to quote R.F. Kennedy without correcting him. How do they know he is wrong? (Well, I mean, apart from having a political prejudice that he must be wrong…)

The worst part of this is that all Kennedy is trying to do is encourage people to be cautious. His hypothesis – a very good one – is that medicine might be dangerous. That’s all.

Consider what the doctors did to Charles II. They killed him, but only after torturing him. I leave you to find out the details.

But here is something funny. The Guardian issued a correction of its piece, written by one Robert Tait. Kennedy had said that he was “was committed to investigating the ‘etiology of the autism outbreak’”. But Tait, quite naturally having politics on his mind, misheard Kennedy and wrote “ideology”.

This article was amended on September 23rd 2025. An earlier version quoted Kennedy as saying autism had an “ideology”; however, Kennedy said “etiology”.

Ha, ha, ha. Well, of course this daft Left-wing journalist thought he had heard Kennedy say that autism has an ideology.

Let’s continue down the rabbitol.

Heidi J. Larson, in a paper entitled ‘A crisis of credibility: the global cost of US vaccine misinformation‘ for the Lancet last month, says that the “global health community” is suffering from a “pandemic of misinformation”. “The USA functioned as a major exporter of COVID-19 vaccine misinformation,” etc.

Aye, so it did. So did the UK. So did the Lancet. Still does.

The sad fact is that Streeting, the Guardian, are all wrong. There is research supporting a relation between autism and Tylenol. But, they say, listen to the science. By which they mean this science. Which means, of course, not that science. Not the science being used by Kennedy and Trump.

Last month, the Harvard T.H. Chan School of Health in a piece entitled ‘Using acetaminophen during pregnancy may increase children’s autism and ADHD risk‘, advertised an academic article by one of its professors published in a journal called Environmental Health.

The researchers analysed results from 46 previous studies worldwide that investigated the potential link between prenatal acetaminophen use and subsequent NDDs in children. The researchers used the Navigation Guide Systematic Review methodology — a gold-standard framework for synthesising and evaluating environmental health data — which enabled them to conduct a rigorous, comprehensive analysis that supported evidence of an association between acetaminophen exposure during pregnancy and increased incidence of NDDs.

NDDs are neurodevelopmental disorders. Anyhow, sounds scientific enough: systematic review, gold standard all that, plus Harvard. How about that for an authority? And what did this authority urge? It urged – caution.

Andrea Baccarelli of Harvard wrote in a statement to the White House: “Further research is needed to confirm the association and determine causality, but based on existing evidence, I believe that caution about acetaminophen use during pregnancy — especially heavy or prolonged use — is warranted.”

Further study? Caution? Aye, Streeting, makes you aghast, does it? Aye, Guardian, has you reaching for your compliant regime experts to shout this down, does it?

Of course Trump exaggerated. He said, “Don’t use Tylenol.” Well, he is a politician. Don’t trust him. What he meant was, “Be cautious.” What do the scientists say? Well, one of them, Ann Bauer, one of Beccarelli’s co-authors, said, in effect, as I paraphrase, ‘Be careful, you may still use it, but do so in an informed way.’

Back to the people on the incautious side:

Streeting said: “It’s really important that at a time when you know there is scepticism – and I don’t think scepticism itself, asking questions, is in itself a bad thing, by all means ask questions – but we’ve got to follow medical science.”

In other words, don’t be sceptical. Not about this. Not when doctors are involved. And bear in mind that Streeting is trying to pose as a serious politician. Whereas he is in fact the irresponsible one.

Maybe he’ll start telling the truth when no longer Secretary of State for Health and Social Care.

The only observation about all this that I found even slightly convincing was an argument Bret Weinstein made when talking to his wife on the Dark Horse podcast. Tylenol replaced aspirin in the 1970s, when it was found that aspirin was dangerous during pregnancy. The irony. But the argument is a general one, not a specific one.

Bret Weinstein said, and again I paraphrase: “The fact that we do not know it is unsafe now does not mean it is safe.”

It is a matter of historical that scientists in the past said ‘It is safe’ whereas scientists in the present say, ‘Alas, in truth, it was not safe.’ So is it not evidential, factual, practical to say, in response to the doctors and authorities advocating a medicine about which there is some doubt, or even about which they may be some doubt, ‘Let us be cautious!’

According to the regime scientists and their stooges in ministries and the newspapers and the universities, apparently not.

Nature tells us that “scientists say that strong evidence between the medication and autism is lacking”.

Well, zarking fardwarks, was there any strong evidence at any point for any governmental-scientific intervention during the pandemic of misinformation that was the COVID-19 pandemic?

Nature means that there is no established causality, that strong word, demonstrating without a doubt that, say, Tylenol/Paracetamol causes autism. There is only a correlation, and, indeed, a disputed correlation. Fair enough. But should we not be cautious?

Why is it ‘The Science’ to behave like sheep when a favoured dog barks a bit rabidly but not when a wise old hound urges caution?

Let’s listen to Whoopi Goldberg, as if addressing Trump on the View: “RFK Jr is not a doctor. And you, sir, are not a doctor. And you don’t have any understanding, clearly, of why people take Tylenol. It’s been around forever. There are all kinds of studies… I’m not listening to you any more…!”

Reassuring, ain’t it? She mentions that the manufacturers of Tylenol have found (cough, paid for?) research to reassure us that everything-is-all-right. Good! What she does not mention, however, is that she is not a doctor. Or that even if she were a doctor it would not mean very much. COVID-19 demonstrated that. Anyhow, Whoopi Goldberg: the best we can say of her is that, like the scientists, she is a dependent variable.

Overall, nothing to see here at the bottom of the rabbitol.

In sum, a Government has urged caution and will pay for more research into the causes of autism. The story, as usual, is not the story, but the response to the story in the flouncing and preening and grifting of the dependent variables.

James Alexander is a Professor in the Department of Political Science at Bilkent University in Turkey.

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NickR
6 months ago

TTE, Heneghan & Jefferson’s Substack is my 1st port of call on these sorts of questions.
They tend to identify the junk, flawed or compromised science from the better stuff.
On Tylenol they seem to be saying, probably a weak association, be cautious.

10navigator
10navigator
6 months ago
Reply to  NickR

Ditto.Eternally grateful to Profs Heneghan and Yeadon who were beacons during Covid, lighting my way past the jibby-jab obstacles.

Tylney
Tylney
6 months ago
Reply to  NickR

Another substack article on exactly this topic, this from a medic who takes the time to investigate many products alleged to be ‘safe and effective’

https://www.midwesterndoctor.com/p/why-does-tylenol-cause-chronic-illnesses

GroundhogDayAgain
6 months ago
Reply to  Tylney

By the nuanced way he/she writes I believe MWD has integrity and is worth listening to.

Every medicine in the UK comes with an information leaflet, and these leaflets summarise the adverse outcomes.

Let’s not forget, it takes very few paracetamol for a fatal overdose. But clearly safe, right?

Anyone who speaks about 100% safe, clearly has no idea.

Less government
6 months ago

Alas the Covid injections did not come with an information leaflet explaining the adverse outcomes or any worthwhile informed consent.

Hound of Heaven
Hound of Heaven
6 months ago
Reply to  NickR

Do parents need to be cautious with Calpol?

DiscoveredJoys
DiscoveredJoys
6 months ago

Yes, we should be cautious. But a lot of Climate Change Alarmism was driven by the precautionary principle to the point of seizing control of the Anthropogenic Warming ‘certainty’.

So it seems wise to be cautious about being cautious… but the precautionary principle suggests that trivial use of paracetamol in pregnancy should be avoided.

Who knew cause and effect was so fuzzy? My head hurts.

Jon Garvey
6 months ago
Reply to  DiscoveredJoys

There’s a lot of difference between the precautionary principle that says a virus might just be uniquely deadly, and that therefore society should be shut down and everyone in the world given experimental drugs on pain of imprisonment and forbidden tried and tested ones; and the precautionary principle that says don’t take a drug with some dodgy potential unless it’s absolutely necessary.

DiscoveredJoys
DiscoveredJoys
6 months ago
Reply to  Jon Garvey

I agree – for normal people. But to an activist any lever is worth pulling good and hard, especially if the argument is thin.

st27
st27
6 months ago
Reply to  DiscoveredJoys

That’s a wonderful image, fully explaining how this works.

“An activist takes a thin argument, builds a thick (in all senses) lever from it, and then pulls the lever hard”.

kev
kev
6 months ago
Reply to  DiscoveredJoys

Where exactly was the precautionary principle when it came to the so-called Covid vaccines, especially the never before used on humans mRNA gene therapies?

Science said “Safe and effective”, our survey said “0”

When you need to decide which science to follow, opt for the one that allows you to question it and debate it, not the one that silences and threatens you and can destroy your career.

Most advice emanating from “The Science” surrounding the whole Covid debacle, and also the Climate debacle was/is based on an “abundance of caution”.

Trump and RFK Jnr just went for a mediocre amount of caution, not an abundance, but that was somehow Misinformation or maybe Disinformation. They did not say Tylenol causes Autism, expectant mothers should not take it, they advised caution, until further tests are undertaken.

Mrs Bunty
6 months ago
Reply to  kev

When you need to decide which science to follow, opt for the one that allows you to question it and debate it, not the one that silences and threatens you and can destroy your career.”

Bravo, wise words. I wish more people heeded them.

LizT
LizT
6 months ago
Reply to  DiscoveredJoys

False equivalence. Being cautious in respect of drugs ie choosing not to take them is a personal decision that affects that person (and an unborn child in this case.) Being “cautious” in respect of climate change is meaningless. The climate has changed since time immemorial and has very little – I would argue nothing – to do with what mankind does

transmissionofflame
6 months ago

“Streeting said: “It’s really important that at a time when you know there is scepticism – and I don’t think scepticism itself, asking questions, is in itself a bad thing, by all means ask questions – but we’ve got to follow medical science.””

ROFL!

People lie all the time, but Doctors, “Scientists” and bosses of Big Pharma firms never lie for personal gain. Even with compliant regulators and morally bankrupt governments, Big Pharma have still been fined probably trillions for cheating.

Less government
6 months ago

Big Pharma, probably the most litigated industry in the world already, and definitely soon, if RFK Jr., and the new team gets the truth out.

jeepybee
6 months ago

Why are the left so vehemently against the idea that ingesting or injecting chemicals is potentially bad for a developing baby? They’d know not to drink alcohol…

Plus this nonsense of “Trump said” as if he were the one conducting his own research on these things! It’s like they don’t understand the concept of learning.

Tyrbiter
Tyrbiter
6 months ago
Reply to  jeepybee

The Left appear almost incapable of any kind of learning, and essentially have been ever since the term “Left” was coined.

Jane G
Jane G
6 months ago

Yes – it’s always wise to be cautious and I agree with NickR about TTE with Heneghan and Jefferson.

What made me boggle in this article was that the author, despite finding the beam in the eye of the Guardian ‘experts’, appears to trust the MHRA, UKHSA and the other ‘approved barking dogs’.

Gawd’elpus!

Tyrbiter
Tyrbiter
6 months ago
Reply to  Jane G

I didn’t get that from the article, quite the opposite.

GroundhogDayAgain
6 months ago
Reply to  Jane G

I took that as ‘tongue in cheek’. I trusted them once, but not anymore.

Less government
6 months ago
Reply to  Jane G

Indeed, two repulsive organisations that should be shut down along with the WHO.

GlassHalfFull
6 months ago

There are many causes of autism with paracetamol possibly being one of them.
There are many scientific papers showing a possible link between paracetamol, vaccine ingredients and autism.
It has always been the case that politicians make announcements after receiving medical and scientific advice.
Trump has surrounded himself with these professionals who have a more openminded view on the causes.
People should be pleased that there is now “real” research into ALL causes of autism and are warning their citizens of the possible harms.

GlassHalfFull
6 months ago
Reply to  GlassHalfFull

Knee-jerk opposition to the warning-label update for Tylenol is not warranted, given that there is evidence in the scientific literature providing cause for concern about possible negative neurodevelopmental effects of Tylenol. For example: Ji et al., “Association of Cord Plasma Biomarkers of In Utero Acetaminophen Exposure With Risk of Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in Childhood”, JAMA Psychiatry (2020): https://pubmed.ncbi.nlm.nih.gov/31664451/ Conclusions and relevance: Cord biomarkers of fetal exposure to acetaminophen were associated with significantly increased risk of childhood ADHD and ASD in a dose-response fashion. Our findings support previous studies regarding the association between prenatal and perinatal acetaminophen exposure and childhood neurodevelopmental risk and warrant additional investigations. Bauer et al., “Paracetamol use during pregnancy – a call for precautionary action”, Nat Rev Endocrinol (2021): https://pubmed.ncbi.nlm.nih.gov/34556849/ We recommend that pregnant women should be cautioned at the beginning of pregnancy to: forego [acetaminophen] unless its use is medically indicated; consult with a physician or pharmacist if they are uncertain whether use is indicated and before using on a long-term basis; and minimize exposure by using the lowest effective dose for the shortest possible time. Most recently, in August 2025, the Dean of Harvard’s School of Public Health co-authored a review paper… Read more »

RW
RW
6 months ago
Reply to  GlassHalfFull

As an old German joke goes: What this? It’s hanging on a wall and says “Tick – tack – tick – tack – tick – tack¹ …” and when it falls down, the garden door opens.

Answer: Coincidence.

¹ German phonetic approximation of the sound an old-fashioned, mechanical wallclock makes.

GlassHalfFull
6 months ago
Reply to  RW

If you are saying that paracetamol and vaccine ingredients causing autism is just a coincidence then you are agreeing with the “establishment” view and is not very “sceptical” of you.

RW
RW
6 months ago
Reply to  GlassHalfFull

I’m saying that one bazillion unexplained correlations are just that — unexplained correlations. If we just know that a correlates with b, we just know that a correlates with b. No further concusions can be drawn from that.

RW
RW
6 months ago
Reply to  GlassHalfFull

Such-and-such a person is guilty of autism¹ is still an opinion someone who claims to be an expert on human behaviour has formed for some reason. There’s no way to measure autism. There’s no way to rerun some pregnancy plus the complete life of someone until such an opinion came to be formed with just one factor changed to see if this will cause the opinion to be formed again or not to be formed again. Hence, scientific research into the causes of autism is impossible.

Anything beyond that is politically motivated mumbo-jumbo.

¹ Culpably responsible for anything others might do to him, no matter what it is, explicitly including criminal violence, and regardless of the reason why they did it to him. That’s not a joke. It’s how things usually turn out.

GlassHalfFull
6 months ago
Reply to  RW

I am aware of all the scientific and medical papers around autism and I am convinced there is a link.

“Nearly every single study of a link between vaccines and autism does NOT compare the vaccinated against the unvaccinated and therefore every single one of these studies is flawed.
We also have the eyewitness testament of tens of thousands of parents who saw their children decline within a short period just after being vaccinated.
The holy grail in autism research is to find vaccinated vs. unvaccinated studies. Thankfully there are now six good studies that we can rely on.
All find a link between vaccines and autism.”

GALLAGHER & GOODMAN (2008 & 2010)
MAWSON (2017A)
MAWSON (2017B)
HOOKER (2021)
MILLER (2021)
MAWSON & JACOB (2025)

https://tobyrogers.substack.com/p/mapping-the-entire-field-of-autism

RW
RW
6 months ago
Reply to  GlassHalfFull

It’s autism! is an opinion. The so-called scientific method requires repeatable experiments. Experiments can only be repeatable if the outcome can be measured. Opinions can’t be measured. Ergo: Finis scientia.

Hound of Heaven
Hound of Heaven
6 months ago
Reply to  RW

If that is true then no neuropsychiatric disorder can be diagnosed.

Gezza England
Gezza England
6 months ago
Reply to  GlassHalfFull

I know two people who had a normal child until the MMR jab ruined the child’s life and to some degree the parents lives too.

I have seen it said that there is a very good sample population of the unvaccinated – The Amish. Incidence of autism – zero.

MajorMajor
MajorMajor
6 months ago

I don’t have a clue whether or not Paracetamol can harm pregnant women.
But the assumption that science and the medical profession are always right is laughable. You have to be really gullible to believe in that.

Hound of Heaven
Hound of Heaven
6 months ago

Electromagnetic fields from all IT is also under suspicion. That could be very inconvenient if proved to be true.

Tyrbiter
Tyrbiter
6 months ago

What would the mechanism for that be? The only proven effect of E-M energy is thermal heating and that is only in areas without much blood flow cooling such as the lens in the eye.

Hound of Heaven
Hound of Heaven
6 months ago
Reply to  Tyrbiter

There is ongoing research on this. I am not qualified to judge it but that doesn’t alter the fact that it is under investigation, particularly in America.

Hound of Heaven
Hound of Heaven
6 months ago
Reply to  Tyrbiter

The mechanism is described thus: “This harm occurs through voltage-gated calcium channels (VGCCs) located in your cell membranes. VGCCs are highly concentrated in the brain, and animal studies have demonstrated that even low levels of microwave EMFs produce significant and diverse effects on brain function. When EMFs activate these VGCCs, it results in a variety of neuropsychiatric issues.” (Rev Environ Health, 2015;30(2):99-116.)

modularist
6 months ago

Causation of neurodevelopmental issues shown in rodents I believe.

To my mind, it makes sense. We don’t give babies adult doses of acetaminophen, and the drug crosses the placental barrier.

This has all been blown up though. On this side of the pond, there is a warning on the insert for pregancy. In the US there has not been, and now there will be.

Changing eligibility for Covid boosters to something like the rest of the world was blown up too and treated as clear evidence of anti-vax status.

It’s all transparent now – anything RFK says will automatically be torn apart until Pharma/Ag have got rid of him. If it was coming from a Dem appointee then it would not treated like this.

DiscoveredJoys
DiscoveredJoys
6 months ago
Reply to  modularist

A Dem appointee wouldn’t rock the boat.

JDee
JDee
6 months ago

As I understand it paracetamol disables part of the mechanisms for cleaning out toxins. So it’s not the paracetamol per-se but what it then stops the body doing to other stuff. So particularly dodgy when used in conjunction with other medicines such as vaccines with the very young when brains are not yet fully formed. Yes it needs more research.

By the way during COVID I wrote to Streeting multiple times to try and get him to wake up to the unfolding disaster .He is therefore completely culpable for the mess. He clearly cannot think for himself and just defers to the current politically safe position. At some point in the very near future an extensive study previously held back, of all health outcomes comparing vaxed to unvaxed will be published. This will go off like a bomb. Steering and MSM will either ignore or denigrate this as well. Check out Del Big Tree and the Highwire who have in fact be leading the way on the COVID vaccine fight back

chesterbear
chesterbear
6 months ago

Serious question how do you cautiously take a medicine? Does it mean if you have a headache take 1 tablet instead of 2? Then it might not work so it was pointless even taking the one. I’m honestly confused.

Jon Garvey
6 months ago
Reply to  chesterbear

It’s really no more difficult that being cautious about taking out your smart phone in London.

“I’m in the last weeks of pregnancy. Do I want to risk my kid getting autopsy for a frigging headache?”

“Kiddo has a high fever. Pyrexia is a natural response to fight infections, and anti-pyretics may prolong illness. The only significant danger is febrile convulsion below the age of 5 years, and there’s no research evidence that anti-pyretics prevent them. However, tepid sponging reliably limits fever without pharmacological risk, so maybe I’ll start with that. Above the age when autism is a risk, paracetamol may help a sore throat or earache, but it doesn’t help sick children sleep. I seem to know enough to limit the use of paracetamol.”

“There’s no known risk from adults using single doses of paracetamol for headache. But on general principles, is this particular headache bad enough to warrant popping anything anyway? I know enough to use it pretty safely… and I won’t overdose on it if I’m suicidal, because it won’t knock me out but may make me die slowly of liver failure when I’ve regained my love of life.”

GroundhogDayAgain
6 months ago
Reply to  Jon Garvey

Did you mean ‘autopsy’ in your second paragraph? 🤔

GroundhogDayAgain
6 months ago
Reply to  chesterbear

I’m of the view that popping a pill for a headache is rarely the best choice. For extreme pain, maybe.

Jon Garvey
6 months ago

A very good article, simply because he didn’t take the MSM on trust, but asked simple questions. But he should be careful about Rabbitol, which has been associated with autism.

But at the news conference, even Trump didn’t simply say “Don’t take Tylenol.” Essentially he said avoid it unless you really can’t, or if advised by your doctor. And he added the caveat that he was going beyond the scientific caution of the doctors standing behind him.

RW
RW
6 months ago

It’s unclear if Paracetamol works at all and assuming it does, how it accomplishes what it’s said to accomplish. But the side-effects of it are very real and once, caused me to need an emergency appointment with a doctor who put me on beta blockers (good enough to hamper the immediate symptoms) I then slowly weaned myself off again. These symptoms eventually vanished almost completely, but this took years.

Ergo: Don’t take Paracetamol. That would be my advice based on very bad experience with it (no overdose involved, just continued use for a couple of weeks).

Jon Garvey
6 months ago
Reply to  RW

The reason it doesn’t work is that it’s white. I had a consultant boss who recounted that his Dad, an old fashioned GP, had special yellow pills made up to dispense to his patients for various conditions. They all swore Dr Hamilton’s pills were magic. One day, my boss asked him what they were – it was aspirin.

Old medical adage: red pills work best, and never inject anything green and sticky.

RW
RW
6 months ago
Reply to  Jon Garvey

I’m just relaying medical information I remember: Some researchers claim Paracetamol works. Others claim that if it has any effect, this must be a placebo effect. Nobody knows how it works if it does work.

I know that it has very real and really unpleasant side effects after taking it for a while.

Jon Garvey
6 months ago
Reply to  RW

I certainly agree that it doesn’t work for my headaches. Ibuprofen does, and that’s white too, so I suppose I’ve disproved my own point 🙁

JASA
JASA
6 months ago
Reply to  RW

Why did they prescribe you a beta blocker? N-Acetylcysteine (NAC) helps protect the liver from paracetamol metabolites, by replenishing glutathione, hence why high doses of it are used in A&E departments for paracetamol overdose. You don’t have to have taken packets of the stuff and deliberately overdosed, as it can accumulate with prolonged use. Most people who take paracetamol pretty regularly would be sensible to consider supplemental NAC to mitigate potential liver risks.

RW
RW
6 months ago
Reply to  JASA

Because, based on the symptoms, he claimed to have diagnosed anxiety, whatever that specifically means.

My nasty suspicion about that would be: Beta blockers are an introductory pathway towards regular medication. He offered to put me on blood pressure tablets later. But then, thankfully, as I have to say here, COVID happened and he forgot about me again. Hence, I’m still medication free as normal state of affairs.

Boomer Bloke
6 months ago

The patient information leaflets for generic paracetamol (16x500mg bought in Tescos for about threepence halfpenny) and generic ibuprofen (16x200mg bought in my local Spar convenience store for a bit more than that) both advise caution during pregnancy worded in quite different ways, because that is what the post marketing data of millions of doses taken by millions of people over several decades indicates. It’s not rocket science. The message not to drink alcohol while pregnant or breastfeeding seemed to go over with little or no controversy decades ago. It’s not much of a stretch to advise caution with OTC medicines as well, when that is what the data is saying. And where are the Medical SVPs of the big OTC brands on this? (J&J, GSK, etc…). You would think they would be jumping all over the media very quickly with their data and carefully curated analysis to defend their brands if President Trump was wrong. Perhaps what we need is an OTC treatment for TDS.

JohnK
6 months ago

Sightly off topic, but many are cautious about taking paracetamol in tandem with alcoholic drinks. Lots of articles on that issue, such as: https://www.bps.ac.uk/publishing/our-journals/british-journal-of-clinical-pharmacology/volume-49/issue-4/paracetamol-alcohol-and-the-liver

Sforzesca
Sforzesca
6 months ago

Aspirin/salicylic/acid/willow bark has been used for over 3,000 years.
The whole of the precise biomolecular mechanisms are unknown, save the simple answer is that it blocks production of prostaglandines which are maybe just one cause of inflammation thus reducing pain.
The downsides – eg lengthening healing time and arguably in some causing intestinal bleeding – are well known.
But, the whole of the actions are as yet unknown – as is the whole potential for other benefits..
So, good luck in assessing the costs/benefits of tylenol, a much simpler molecule.
That said there are of course enormous benefits to bigpharma….

Western Firebrand
Western Firebrand
6 months ago

I listened to the Nigel Farage interview with Nick Ferrari live on LBC. I thought that NF’s answer was quite reasonable in that science is never settled and he was keeping an open mind.

The opprobrium dished out since by other parts of the spectrum (political, not autistic) was that he didn’t toe their line and condemn Trump’s comments in line with their faith in “settled science”.

Wes Streeting (my MP, as it happens, though perhaps more a representative of the WHO than Ilford North) continues to rubbish Reform – today an attack on Dr Malhotra for daring to suggest that the emerging (after being suppressed) link between Covid vaccines and life-limiting illness might even have reached the Royal Family.

Myra
6 months ago

Tice during Question Time clearly had not done his homework and said paracetamol is safe and Trump was wrong.

LizT
LizT
6 months ago
Reply to  Myra

Tice is a fool

JXB
JXB
6 months ago

““RFK Jr is not a doctor.” What’s the weather like today? I don’t know I’m not a meteorologist. Science is not a book of revelation. There are no facts, just accepted temporary theories – and it doesn’t matter how long a theory has been accepted, it’s is still only temporary because it may change because of new discoveries in the future. “I trust doctors over President Trump, frankly, on this,” he said. “I’ve just got to be really clear about this: there is no evidence to link the use of paracetamol by pregnant women to autism in their children. None. So I would just say to people watching: don’t pay any attention whatsoever to what Donald Trump says about medicine. In fact, don’t even take my word for it, as a politician – listen to British doctors, British scientists, the NHS.” Oh? And what did British doctors, British scientists, the NHS… and, oh yes, the pharmaceutical industry say about the cause of gastric ulcers? Caused by stress. And the pharmaceutical industry had developed Proton pump inhibitors to reduce the acid produced, treat the symptoms but no cure, so patients kept taking it. It was a £multi billion product. Soooooooooo…. Trust… Read more »

LizT
LizT
6 months ago
Reply to  JXB

I would also say look at statins. One of the most side-effect prone useless but profitable drugs in history that Big Pharma tried to force upon everyone over the age of 40. I know people who have been terrified by their doctors into taking it who experienced such horrendous side effects that they could hardly walk because of the pains in their legs. Independent research shows they have zero value to anyone

GroundhogDayAgain
6 months ago
Reply to  LizT

Malcolm Kendrick has written a wonderful book titled “Doctoring Data”, which I heartily recommend.

Also “The Great Cholesterol Con” which I haven’t read.

GroundhogDayAgain
6 months ago
Reply to  JXB

In the early 20th century, bed rest was seen as as the only correct treatment for a heart attack patient. The “science was settled”

When research suggested that mild exercise may be preferable and that bed rest might instead be harmful, the medical professionals responded with accusations and character assassinations.

Now it’s not controversial in the slightest.

Curio
Curio
6 months ago

Could the Big Pharma’s assets (see list in this courageous article) explain why “Autism spectrum disorder (ASD) diagnoses have steadily increased in the U.S., with prevalence rising from 1 in 150 in 2000 to about 1 in 31 children by 2022”. Quite a jump from “1943, 11 cases”.
It’s big bucks for those on the list

RW
RW
6 months ago
Reply to  Curio

Until physical symptoms of autism have been identified, the question is moot because it can’t be answered. That’s what research into autism would need to do first.

Tyrbiter
Tyrbiter
6 months ago

I was born in 1963, my mother had a miscarriage in 1960 which increased her concern over drugs in pregnancy but that was informed by the recent, then current, thalidomide scandal that blew up in the late 50s and early 60s.

Her view, and a very sensible view, was that she would not take *any* prescribed drug during pregnancy unless it was essential or unavoidable. That minimises the risk from drugs but of course does not minimise the risk of the lack of drugs, it was a desire but not an absolute one.

We should all use our noggins to decide for ourself with information that is available for our own assessment.

I don’t trust politicians to tell me what to think, as as for Ms Goldberg, I’ll let you know when I have climbed back into the chair I’ve just fallen off.

wryobserver
wryobserver
6 months ago

I wonder whether Messrs Trump and Kennedy are competent to decide on these arcane medical matters. Oh, I forgot. They are advised by medical experts. Could it be they are passing on what they have been told? The baying mob have thrown in the old thing about Trump suggesting people should be taking bleach for Covid so he must be crazy. But look up chlorine dioxide and check what it’s used for. Safe as anything. And it’s, er, bleach. Kennedy’s statements have been firmly supported by his experts, it’s just that they might be the right experts at last…

NubOfTheMatter
NubOfTheMatter
6 months ago

Don’t worry Wes, we don’t take your word for anything – nor that of any of your fellow members of the Lab/Lib/Con political class. But for a few notable exceptions, professional liars all.
unfortunately, the same has to be said of the ‘experts’ you rely on. Together you almost killed the British economy with your collective, evil Covid response (and in some cases became corruptly wealthy in the process) ; and who knows what havoc is awaiting future generations from the long term effects of the gene-therapy Covid injections you all still insist are ‘safe and effective’ but never, ever were. You people represent a stinking stain within the long history of humanity.
Hopefully, Reform will ‘drain the swamp’ and provide at least a few parliamentary cycles of honest politics.

Corky Ringspot
6 months ago

“zarking fardwarks”?

Love your articles Prof, but uh?

harrydaly
harrydaly
6 months ago
Reply to  Corky Ringspot

Ditto

LizT
LizT
6 months ago

Streeting was reckless in his response to Trump, something which he may later regret.

Myra
6 months ago

It is astonishing how anything Trump
or Kennedy say, immediately is twisted when reported. But I would have expected Wes Streeting to be a bit more cautious in his assessment.
I nowadays go to the actual press release to work out what was actually said, but most people don’t.

Spiv
Spiv
6 months ago

Not parroting Trump who has turned hyperbole into an art form, but looking at who is doing all the pearl clutching hysterical response to even looking deeper at the issue, that worries me.
I swallowed the kool aid and enthusiastically proffered my arm for five separate COVID jabs until in twenty-four hours after the last one, I lost 65% of my blood cells.
This is not a made-up side effect and it is mentioned on the vaccines own website and was duly recorded on the ‘yellow form’ near miss system by my GP.
Funny thing. Nobody mentioned this rare side effect when I went for the jab, you have to examine the fine detail on the website to see it.
I wouldn’t trust Trump at gunpoint to give me health advice as he is no more a doctor that Whoopi Goldberg. But if there is a link to autism, particularly when we are seeing a truly massive increase in Autism, ADHD and similar conditions in children, shouldn’t we at least find out why?

GroundhogDayAgain
6 months ago
Reply to  Spiv

Glad you’re okay now, but sorry you went through five jabs before your rude awakening. Any lasting effects?

Those who tried to raise concerns were traduced, mocked and entirely shut out of the national conversation.

I also think that some of the craziest, most easily mocked concerns were started by the intelligence agencies as a means to discredit by association the more reasonable voices.

Absence of evidence isn’t evidence of absence.

My main reason for refusing the jab at first was the batshit way they were forcing it on the population. Realising informed consent was absent I dug in my heels. Only later did the evidence of harm emerge, but I’m so glad I trusted my spidey-sense.

st27
st27
6 months ago

Excellent coverage. As usual, the truth – which we don’t know yet – lies somewhere in the middle. There may well be a causal link between tylenol and foetal problems.

Of course Trump postured and exaggerated. Of course Streeting – a nasty little piece of work – responded by posturing and exaggerating in turn; adding a little swipe about “anti-vaccine misinformation”, when in fact this debate has nothing to do with vaccines. But of course Streeting, and that cavalcade of “vaccine-hesitancy-Experrrrrrts” backing him, already _hates_ RFK, the new ACIP and the new CDC and NIH, because they’re also – in another room – questioning the Pressssshous Vaccines. So he’s getting in his shot (pun intended) early. Expect more “anti-anti-vaxx” nonsense from Streeting, coming soon!

I hate Streeting already because of his personal prejudice against vaping, which has been incarnated as a dreadful Bill.

GroundhogDayAgain
6 months ago
Reply to  st27

I forget where I saw it, but I believe there was also a 2019 Johns Hopkins study which also found a connection.

Plus something from Tylenol themselves saying caution is advised.

JeremyP99
6 months ago

Tylenol advise

“Not to be taken by pregnant women”…

Less government
6 months ago

The Global medical fraternity is completely shot. The integrity of the journals and regulators virtually non existent. Most bought and paid for. Big Pharma whores.

Less government
6 months ago

Not that long ago GPs sternly advised pregnant women not to be reckless with the consumption of blue cheese or a glass of wine.
Now it seems anything goes, especially those magical slimming pills that are apparently safe and effective. A ticking time bomb waiting to go off.