Bird Flu Has Mutated to Infect People, Scientists Claim – But No Human-to-Human Transmission

A bird flu strain that claimed the life of a schoolgirl in Cambodia has evolved to better infect human cells, in a worrying sign. The Mail has the story.

Scientists on the ground who made the discovery said the finding “needs to be treated with the utmost concern”.

They added that there were “some indications” the virus had already “gone through” a human and picked up the new mutations before infecting the girl.

The 11-year-old girl, from Prey Veng province, last week became the first victim of H5N1 in 2023. Her father has also tested positive for the virus but has not developed symptoms.  

Dr. Erik Karlsson, who led the team at the Pasteur Institute of Cambodia that decoded the genetic sequence of the girl’s virus, warned that it differed from that taken from birds.

He told Sky News: “There are some indications that this virus has gone through a human. Any time these viruses get into a new host they’ll have certain changes that allow them to replicate a little bit better or potentially bind to the cells in our respiratory tract a little bit better.”

But he added that the virus was yet to fully adapt to humans, saying it was fundamentally “still a bird virus”.

Dr. Karlsson said the new mutations were unlikely to have occurred in the girl, but probably existed in a “cloud” of viruses with random genetic changes inside birds. 

The strain in its current form is unlikely to cause a major outbreak. Widespread transmission would require a mutation that allows it to bind to a receptor found on cells in the nose. 

Genetic testing revealed that the girl had caught the 2.3.2.1c strain of H5N1, which is endemic to wild birds and poultry in Cambodia.

This differs from the 2.3.4.4b type that has spread rapidly around the world and infected many birds and mammals, but Dr. Karlsson said this was no reason to downplay the threat.

He added: “This was zoonotic spillover [of a virus infecting a new species] and needs to be treated with the utmost concern.”

Calling on the world to keep monitoring the virus, he said: “Something may be happening here in Cambodia and something may be happening on the other side of the world in South America, but we don’t really know what could cause the problem tomorrow.”

H5N1 has a human mortality rate of around 50%. There have only been around 870 cases among people ever, globally.

The 2.3.4.4b strain has devastated the world’s bird population over the past year.

More than 15 million animals have been struck down and killed by the virus itself, while governments have collectively culled more than 200 million worldwide to curb the virus’ spread, including 58 million in the U.S. alone. 

Worth reading in full.

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NeilParkin
3 years ago

Let me guess. They already have a vaccine available. Form an orderly queue…

Freddy Boy
3 years ago
Reply to  NeilParkin

Pregnant women & Babies to the front please !

amanuensis
3 years ago
Reply to  NeilParkin

I’m sure that this is the case, but it’ll be as effective as other influenza vaccines, ie, not very effective at all.

This is independent of the technology used to deliver the viral epitopes to the individual — the ‘problem’ is the way the immune system deals with different types of infection (it probably isn’t a problem but a highly evolved mechanism to stop certain bad things from happening due to the immune response — something which would be bypassed with efforts to deliver a long lasting ‘protection’).

johnboy12
3 years ago

Bill & Melinda Gates Foundation – Committed Grants
Pasteur Institute of Cambodia
Division
Global Health
Date
DECEMBER 2022
Region served
GLOBAL+1
Committed amount
$411,525
Grant topic
Enterics, Diagnostics, Genomics & Epidemiology
Duration (months)
19
Grantee location
Phnom Penh,Cambodia

Dec 2022, nothing to see here folks

amanuensis
3 years ago

This sort of thing happens all the time — it is just that it’s only recently that we’ve had the medical and scientific technology to track it.

The chances are that if this virus mutates to become significantly more transmissible between humans the change will also be associated with decreased mortality (and disease severity in general). Also, the chances are that it will becomes only marginally more transmissible between humans, at least for a while as it starts to become adapted to its new host (massive and sudden changes in infectiousness are the sort of thing that happens in labs).

The main thing that’s going on here is scaremongering.

Sforzesca
Sforzesca
3 years ago
Reply to  amanuensis

Would you please stop spreading disinformation by informing people of the basics of immunity and viral transmission otherwise they might not be scared enough to get jabbed.
Gates must be rubbing his hands with glee – another global pandemic chance.- and so soon.

The problem for the High Priests of the Jab is that global pandemics don’t actually occur very often.
If I were them I’d wait a good few years longer before trying it on again because the memories of being conned and lied to are likely to linger for a good few years yet.
Hopefully.

ebygum
3 years ago
Reply to  Sforzesca

LOL…The Gates funded GAVI are on it, don’t worry…..

https://www.gavi.org/vaccineswork/why-bird-flu-vaccines-need-urgent-rd

…ready…steady……

JXB
JXB
3 years ago
Reply to  amanuensis

Stop talking sense.

amanuensis
3 years ago

Re this quote: The strain in its current form is unlikely to cause a major outbreak. Widespread transmission would require a mutation that allows it to bind to a receptor found on cells in the nose.  This is unlikely. What is more likely is a viral recombination with the bird flu virus and a endemic human influenza virus (which would occur within a person infected with both viruses at the same time). This recombination is likely to result in a new influenza (thus a pandemic) with fairly similar characteristics to current influenza strains (as it would have enough similarity with strains that people already have exposure to, allowing some immune protection). It is likely that the people most at risk (relative to risks from ‘normal’ influenza) would be the young, who wouldn’t have this prior immunity (not quite as simple as this; the important bit is that it would likely be the young most at risk). We’re likely to hear more and more in the coming weeks about making everyone have the normal flu vaccine in order to reduce this risk. This is pointless because: The risk of the viral recombination occurring will be in those working with poultry, which… Read more »

BurlingtonBertie
3 years ago
Reply to  amanuensis

If viruses exist… Terrain theory vs germ theory rabbit hole needs publicly airing ATL in DS. Without germ theory ie no viruses there is no credible reason to ‘vaccinate’ against a non-existent pathogen. It is the foundation upon which the whole vaccination money making scam has been built. All funded by Rockerfeller…. Follow the money.
No vaccine has been clinically trialled against a truly inert placebo as saline has an effect on the human body. No vaccine has been proven to be effective or safe.
Curtis Cost, Turtles All the Way Down & others have thoroughly debunked the efficacy of vaccines.
Scarlet fever is the true control infection against all the other communicable diseases for which children are injected as there is no vaccine for it. The incidence of scarlet fever over time mirrors the incidence of those other diseases, the incidence of which declined years before the introduction of any vaccine & post improved sanitation in towns & cities. Funny that….

jburns75
jburns75
3 years ago

Rabbit hole sounds like a good description of most alternative hypotheses to explain the manifestations and behaviour of viruses. Please correct me if I’m wrong, but doesn’t Terrain theory hold that viruses do exist, but our susceptibility to them depends on the state of our health, and is more influenced by things like toxins, diet and outlook than the virulence of a virus? Although the idea that a well functioning immune system is conducive to good health is uncontroversial, the claim that viruses effectively don’t exist (or for lack of other factors have no bearing on the severity of disease) seems like an extraordinary one that would require some extraordinary evidence, given the weight of easily accessible evidence which would contradict it, regardless of who funds research. Your Scarlet fever example seems to suggest that viral transmission decreases with reduction of the vectors for transmission (improved sanitation etc.) I’m not sure anyone would argue with that. I’m also not sure anyone has ever argued that vaccines alone are responsible for the ebb and flow of disease outbreaks, which the evidence would suggest is determined more by removal of vectors through death or behavioural change, immune imprinting from infection and viral… Read more »

BurlingtonBertie
3 years ago
Reply to  jburns75

It is precisely because we don’t have full understanding of this issue that it needs to be fully explored above the line. I’m trying to get my head around it. From my limited understanding it is a pathogen which can cause disease in the terrain – bacteria, fungal spores, mould are ones which can be isolated. Viral particles don’t exist outside of a culture. The question that this raises for me is what is being identified if the pathogen can only be detected when it is introduced into a biological soup? I’ve not fully got my head round that one yet. There is a group of folk who are fundamentalists regarding the non-existence of viruses, who are very aggressive in pushing this, doing harm to the scientific process by their behaviour & attitude. I don’t like bullies & wish to form my own opinion based on all the available evidence. Coercion is coercion irrespective of whose doing it! Terrain theory promotes personal responsibility for one’s health, germ theory that someone else can provide the cure is how I see it playing out in the corporate world. Much easier to delegate responsibility than to take it. A lot of the push… Read more »

RW
RW
3 years ago

The so-called Spanish flu first occurred on the Entente-side during world war one and then, jumped over to German soldiers. This is a documented fact and it has been documented by people with no business or other relations to Americans save directing battles against American soldiers. Hence, some sort of mobile disease agent independent of both parties must have been involved there.

BurlingtonBertie
3 years ago
Reply to  RW

Spanish flu only occurred in folk who had received a dose of a vaccine & there was absolutely no contagion as demonstrated in a peer reviewed study published in the BMJ in 1918 where a medic had tried to induce symptoms in healthy disease free ‘volunteer’ soldiers by introducing snot, phlegm & material from infected folk & cadavers as well as being directly coughed, sneezed & spat on. Not one infection occurred. All the folk with Spanish flu had received a vaccine.
Curtis Cost references this in one of his substack articles

RW
RW
3 years ago

This guy suffers from USA is world! disease, like so many of his compatriots and no German (soldier) who came down with flu in 1918 (hundredthousdands of them) had ever received any flu vaccine, especially not an American one, as the USA had broken off diplomatic relations with Germany in winter 1917 and shortly after that, declared war on it.

BurlingtonBertie
3 years ago
Reply to  RW

So can you explain the findings from the peer reviewed & published 1918 study, the same result occurred in another peer reviewed & published study which replicated the original. Something was off in 1918, same as it is now. It wasn’t a flu vaccine. I forget what the vaccine was for but surplus stock was shipped to Europe & side effects weren’t necessarily immediate. Same as with this current bioweapon injection. I’m simply posting information on studies which clearly demonstrate the lack of contagion when infected bodily fluids were transferred from ill, dying & dead patients diagnosed with Spanish flu. I think that you’re doing Curtis a disservice with your comment. He has spent the last 30+ years trying to educate folk about the harms which occur due to vaccinations. He is but one of a number of researchers who having gone to contemporary source material has arrived at the same conclusion. Same as happened with swine flu vaccinations in 1976 & again in 2009, the vaccination campaign for which was halted by Dr Wolfgang Wodarg when he was a member of the European Medical Council. The point which I’m making is that we’ve been lied to for decades about… Read more »

RW
RW
3 years ago

In 1918, the USA and Germany were at war with each other.

BurlingtonBertie
3 years ago
Reply to  RW

That fact doesn’t negate the evidence that it was impossible for a disease free person to be infected by bodily fluids from person or cadaver with Spanish flu.

RW
RW
3 years ago

It negates two very important things:

Caused by US vaccine: As the USA was at war with Germany at that time, it didn’t trade anything with it, let alone medical innovations supposed to keep American soldiers healthy (NB: War is what they do in Ukraine. It means uniformed people trying to kill each other with guns).

No transmission: According to the military historians of the German general staff, the influenza epidemic stared on the Entente side of the front and then, jumped over to the German soldiers.

And, sorry, I consider these more trustworthy than random Americans making factually impossible claims in order to make money on the internet.

BurlingtonBertie
3 years ago
Reply to  RW

How does this relate to clinical research studies peer reviewed & published in 1918 demonstrating no transmission??
The researchers weren’t making factually impossible claim for financial reward on the internet back then! As the results were reproducible, they’re valid. BMJ last time I checked is (well until 2020 anyway) one of the most highly regarded medical journals.

This is the point I’m asking you to consider. War with Germany doesn’t apply to a clinical study, the results of which were reproduced nor to the researchers getting rich on the internet.

There was a disease called Spanish flu which was demonstrated in more than one clinical research study not to be able to transmitted to another individual, despite the researchers’ very best efforts to do so. The question given this hard evidence is what was it that caused the disease in German soldiers ‘cos it sure as hell wasn’t transmitted from the Western Front to the Eastern one?

You’ve repeatedly stated the fact that war was happening without addressing the specific point raised in relation to the clinical evidence.
Please can you address the question rather than repeat that Germany & US were at war. I’ve taken that statement on board.

RW
RW
3 years ago

I’m not in the mood to repeat myself for another time just because you keep repeating the same nonsense like a broken record.

BurlingtonBertie
3 years ago
Reply to  RW

Thank you for your opinion. It’s a shame you were unable/unwilling to bring extra information to the discussion to demonstrate why what I’ve said is nonsense. I’m happy to be proved wrong. By repeating the statement that the US & Germany were at war, which is valid & adds historical context for which I’m grateful, the discussion has been shut down. You could have said that you didn’t have any other views or knowledge.

I am genuinely interested in what folk think about the transmissibility of pathogens, what evidence is out there. It’s a subject that is hugely simplified & under researched & reported. Only by shining a light on & openly discussing things do we all learn.

RW
RW
3 years ago

Historical records demonstrate that. I’ve quoted them verbatim in some other comment. In contrast to this, you just keep parrotting stuff some American crook published on the internet for his own, financial benefit. American vaccines of any shape size or colour weren’t available to German soldiers in 1918, hence, American vaccines can be ruled out as cause for the 1918 flu epidemic. Further, transmission from American/ British/ French soldiers to German soldiers and later, to other German soldiers occured in hundredthousands (and thus, severly impacted the German ability to make war in 1918). Zu alledem begannen jetzt die bisher nur beim Gegner aufgetretenen Massenerkrankungen an Grippe auch auf die deutschen Truppen überzugreifen. https://digi.landesbibliothek.at/viewer/image/AC03617607/410/ In addition to all of this, the mass cases of influenza which had hitherto only affected the enemy troops now started occur in German soldiers as well. Dazu kam die steigende Zahl von Grippe-Erkrankungen an der ganzen Westfront. https://digi.landesbibliothek.at/viewer/image/AC03617607/448/ In addition to this, increasing number of influenza cases occured everywhere on the western front. Bei der Heeresgruppe Deutscher Kronprinz litten fast alle Divisionen mehr oder minder an der Seuche, so daß zahlreiche Änderungen in ihrer Verwendung nötig wurden, da ihre Kampfkraft wesentlich herabgesetzt war. Am 13. Juli… Read more »

BurlingtonBertie
3 years ago
Reply to  RW

Thank you for your further historical context, which I’ve learned from. The issue of terrain vs germ theory has sadly not been addressed as the history books record the history of the victors.
I’m not questioning the historical context regarding what was observed at the time. The question is how does the clinical & real observation of disease described at the time as transmission fit with the clinical research which found no route for transmission?
The problem is that we still don’t fully understand this & one possible solution which has been proposed is side effects of an injected pharmaceutical.
It’s a working hypothesis. The evidence which you’ve forwarded is very interesting but still doesn’t move the debate on this very specific point on.
I don’t have the answers, hence why I’m asking the question.

ELH
ELH
3 years ago

Thank you for airing this argument. I too have read a lot about the Spanish Flu and think there are many more questions to be asked. I am particularly interested in the air pollution experienced by troops after 4 years of artillery fire. In addition I understand that the Germans were malnourished after sanctions and rationing so not in a position to resist illness. Further there is talk of the effects of electrical advances and uses of electricity and finally there is the dosing of the sick with aspirin (recently developed) and its dose-related lethality not fully understood.

BurlingtonBertie
3 years ago
Reply to  ELH

Thank you! I’d forgotten about the lack of nutrition, not considered the air quality nor electrical advances & didn’t know about aspirin.

ELH
ELH
3 years ago

I think it is also worth considering a nocebo effect amongst the troops on both sides of the war – illness would have been their way out. German troops hearing that the French and allies were sickening might have believed that they would sicken too and so they did.

I have a diary of a British soldier in the Middle East who mentions that the hospital orderly, a German prisoner of war, injected all his fellow patients with a needle that he wiped on his sleeve between each injection and that they all died… Techniques were not refined. There is also the memoir of Geoffrey Keynes who was a doctor in a field hospital and they were developing blood transfusions by experimenting on the nearly dead/cases left for dead but didn’t know then about the different blood types. (That was cutting edge/speed of science back then.)

BurlingtonBertie
3 years ago
Reply to  ELH

All very valid points which raise more questions than answers. No NICE protocol diktats back then!!

Sforzesca
Sforzesca
3 years ago

Yes, the unexplainable (by the virus hunters) decline of scarlet fever is always a useful argument to use against the anti anti vaxxers.
The mechanism/s of disease spread and how the the immune system actually works are poorly understood.
This is because there’s no money in trying to find out you see.
And it’s tragic, as well as being the root cause of a lot of matters medical.

huxleypiggles
3 years ago
Reply to  amanuensis

“It is likely that the people most at risk (relative to risks from ‘normal’ influenza) would be the young,”

Billy has already assured us that (his) next plandemic will target the young.

Nice chap that Billy. His last plandemic was targeted at the oldsters so this time he’s sharing more in favour of our young ‘uns. So thoughtful.

JASA
JASA
3 years ago

I really hope that picture is not a real photo. Ridiculous and cruel if it is.

jburns75
jburns75
3 years ago
Reply to  JASA

It’s okay, the chicken was allowed to take it off once it had found a table..
(It looks photoshopped BTW).

True Spirit of America Party
True Spirit of America Party
3 years ago
Reply to  jburns75

LOL

Trev the Geek
3 years ago
Reply to  JASA

I just opened up DS and actually spluttered my coffee over my jumper. That image is too funny.

Who do I send my dry-cleaning bill to?

FerdIII
3 years ago

Ah the magic word ‘evolved’….must be science. Quick, stabbinate all the children.
The virus had a meeting and it was decided to ‘evolve’ and develop some new genetic code from the shit happens programmer. POC successful. On to the beta deployment.

WyrdWoman
3 years ago

No news of any co-morbidities in the unfortunate child, although community malnutrition is mentioned in this article in Nature, plus that it’s part of a viral clade endemic in Cambodia anyway.

https://www.nature.com/articles/d41586-023-00585-1

And – oooh look, they’re going to culture in in the lab! What could possibly go wrong?

‘We will also isolate and grow this virus in our biosafety-level-3 facility, which will help us to develop tools to better understand the epidemiology of this case and the virus in the region. For example, we could develop blood tests for the presence of antibodies — a marker of past infection — in samples collected from the father, other people living in the girl’s home and the broader community. The isolates will also be essential for laboratories around the world to study the virus’s transmissibility and pathogenicity, including in animal models, such as ferrets.’

Mogwai
3 years ago

Oh FFS, what happened to the Marburg over in Equatorial Guinea??😨 I’m running out of brown trousers over here!💩🙈

jburns75
jburns75
3 years ago

What we really need is to create fevered incentives to publish anything and everything around this virus as possible. This will suit the aims of the pharmaceutical industry who can use publicly funded research to harvest patents; academic administrators acting as pimps to secure grants keeping their creaking, bloated management layers fed; politicians holding the purse strings (and who have their back pockets wide open), who always love to be seen to be ‘doing something’; the scientific press now confused between innovation and clickbait; and scientists and academics falling over each other to maintain their publishing record and perhaps even achieve some degree of recognition or celebrity – who doesn’t want a slice of that pie these days? If not enough profitable material can be gleaned from the avian flu virus in its current form, why not create fertile, profitable new ground for all the above interests by publishing about what could happen with it were it to mutate? Of course you’ll need evidentiary material to give your speculation credibility, so better start a programme of cross-breeding the virus with others, perhaps in mice? Perhaps adding new transmissibility vectors through recombination with other highly resilient, human transmissible viruses like HIV?… Read more »

BurlingtonBertie
3 years ago

Seems relevant to post this here as it’s about the efficacy of vaccines, which is what this fear campaign is designed to push:

MORE VACCINES = HIGHER INFANT MORTALITY  
Peer Reviewed Medical Journal Finally Confirms 

There is a century of evidence linking vaccines to sudden infant death

It was predicted that lockdowns would lead to a decline in SIDS due to reduced childhood vaccination and that’s exactly what happened 

Whistleblower, Gary Goldman and Neil Miller did a re-analysis of their original 2011 paper and find that their original conclusion was correct: “A positive correlation between the number of vaccine doses and infant mortality rates (IMRs) is detectable in the most highly developed nations.”

https://journals.sagepub.com/doi/10.1177/0960327111407644

Read Steve Kirsch Substack (https://open.substack.com/pub/stevekirsch/p/more-vaccines-higher-infant-mortality?r=ytl4p&utm_medium=ios&utm_campaign=post)

BurlingtonBertie
3 years ago

Further information to support assertions I’ve made here about the military & racially specific aspects to the bioweapon injections which I’ve received from a US military medic acquaintance. “Not only was it a massive full vaccine campaign but they use dog kidneys flucelVAX by Novartis which increases coronavirus susceptibility by 30% or more https://childrenshealthdefense.org/news/vaccine-misinformation-flu-shots-equal-health/ Key Points- declassify all spike protein information via declassification board headed by Ezra Cohen Watnick Undersecretary of Defense for Intelligence and Christopher Wray of FBI  1. Spike Protein is the financial Bioterror weapon 2. Spike has 4 major components all together giving it racial specificity(Ace2, Furin &Tmprss2 and GP120/41 HIV like attachment) Don’t forget key syncytin In spike not LNP  It’s HervW env/xmrv env like gp120 is hiv env All in VERO cells for noseeum recombination  The Tmprss2 Furin all comes from xmrvs  Don’t need anything else Perfect selective murder weapon. HIV and ACE2 only active after cleaved with TMPRSS2 air Furin so selectively spares Ashkenaziand kills Blacks Browns Italians Irish English and worse if had Flu vaccine- 36% higher chance if take FLUCELVAX.  3. Chinese are killed if assembled onto Coronavirus so unlikely designers of spike.  4. Spike protien Ace2s and GP120/41 have low affinity/ susceptibility… Read more »

RW
RW
3 years ago

I suggest the following treatment everytime someone jabbers about influenza being of utmost concern: Punch him in the face until he shuts up. That’s going to save the lifes of very many people who’d otherwise become victims of hapless medical experimentation.

JXB
JXB
3 years ago

Haven’t we already been through this a few years ago… and pig ‘flu?

Are pandemics to become endemic?

Dinger64
3 years ago
Reply to  JXB

No, we are moving into a new era,
A pandemic of pandemics! all self created!

DomH75
3 years ago

Gosh! I’m so scared! Does this mean I’ll contract it after I get monkey pox? :p

Dinger64
3 years ago

These people live and sleep with their animals, mainly because they have no choice, poverty always leads to the worse case scenario